Our Services

At DSPI we treat a multitude of chronic non-cancer pain conditions.

‘Chronic Pain’ is defined as “any pain that persists beyond the usual recovery period, or, occurs along with a chronic health condition, such as arthritis”. It may also be defined as “any pain lasting longer than 3-4 months”. However, Chronic Pain may be ‘on’ and ‘off’ (continual, but not necessarily continuous) – and it typically affects individuals to the point where they can no longer work, eat properly, take part in physical activity, or enjoy life.

Some of the conditions we treat include the following: chronic headache and migraine, neck and low back pain, sciatica, arthritis and joint inflammation, nerve pain, fibromyalgia, and chronic regional pain syndrome (CRPS). Chronic pain is intimately related to mood and depression, as well as sleep quality, so we may help treat these conditions indirectly as well.

Pain, Insomnia, and Emotional Distress are the three components of the ‘Chronic Pain Triad’, and they affect each other bi-directionally – in other words, each one can make the other two worse, or better.

Someone with significant chronic pain almost certainly also suffers from some elements of depression and anxiety, and/or sleep dysthymia. Worsening chronic pain typically will lead to further decline in mood and sleep hygiene. Conversely, sometimes merely helping to improve someone’s sleep quality or mood, can improve their chronic pain.

All our spine (neuraxial) interventional procedures are performed under fluoroscopic image-guidance. At DSPI we have invested in state-of-the-art fluoroscopic equipment to provide patients the safest and most effective way to perform their spine procedures.

How we do it

Radiofrequency Ablation (RFA)

Radiofrequency ablation (RFA), also called radiofrequency neurotomy, uses radio waves to create a current that heats a small area of nerve tissue. The heat destroys that area of the nerve, stopping it from sending pain signals to your brain. RFA can provide lasting relief for people with chronic pain, especially in the lower back, neck and arthritic joints like the sacroiliac and knee joints.

More information on Radiofrequency Ablation can be found here at the Cleveland Clinic site.

Epidural Steroid Injection

A lower back (lumbar spine) epidural steroid injection is an injection of anti-inflammatory medicine, the steroid, which is combined with some anaesthetic into the epidural space around the spinal nerves in your low back. The procedure may also be performed in the neck (cervical spine), or less commonly the mid-back (thoracic spine).

The main goal of lumbar epidural steroid injections is to manage chronic pain caused by compression, irritation or inflammation of the spinal nerve roots in your low back due to certain conditions or injuries. This type of chronic pain is called lumbar radiculopathy or radicular pain. It will typically radiate down from your low back into your buttocks, hips, legs and/or feet. Lumbar radiculopathy is often what is commonly referred to as sciatica. If present in the cervical spine this radiculopathy manifests as pain radiating down into shoulder, arm and/or hand.

Epidural steroid injections are among the most common type of therapy for managing radicular pain. Back pain is the fifth most common reason people seek medical care, and approximately 9% to 25% of people describe having radicular low back pain per year.

The nature of this ‘nerve pain’ caused by these conditions is referred to as ‘neuropathic pain’. The character of neuropathic pain is typically described by terms such as ‘shooting’, ‘burning’, ‘tingling’, ‘numbness’ or ‘electrical’ sensations. If severe, it can also cause muscle or ‘motor’ weakness, leading to limping, or tripping when walking, or in the case of the arm, a weakened grip and the dropping of items.

Most commonly an epidural steroid injection would be performed in the lumbar spine. Many conditions can irritate the spinal nerve roots in your low back and cause lumbar radiculopathy, including: Lumbar Degenerative Disc Disease, Lumbar Spinal Stenosis, Lumbar Osteoarthritis (Lumbar Spondylosis), Localized Low Back Pain, and Neurogenic Claudication.

More information on Lumbar epidural steroid injections can be found here at the Cleveland Clinic site.

Landmark-Based Nerve Blocks

Using nerve blocks to treat chronic pain can be especially helpful in the treatment of certain chronic tension-type and cervicogenic headache syndromes that have been resistant to more conservative types of management such as mindfulness, lifestyle modifications involving diet, exercise, and the removal of possible environmental triggers; and possibly an adequate trial of pharmacotherapy when appropriate, to address all three arms of the Chronic Pain Triad.

At times, nerve blocks may also be helpful for chronic joint pain to the shoulders, hips, and knees, and others, but more and more we are using ultrasound-guidance for these procedures. When injecting joints, we often add a steroid as a trial of an anti-inflammatory. If this is unsuccessful in providing prolonged relief, we may suggest progression to a more regenerative approach involving either platelet-rich plasma (PRP) or stem cell injections.

The way that nerve blocks work to relieve chronic pain is that they block the incoming or ‘afferent’ pain signals to the part of your brain that senses pain. We know that in people suffering from chronic pain, when we perform a functional MRI (fMRI) that lights up the parts of the brain that are active and firing, the pain centres are lit up in overdrive. This constant firing into these pain centres will over time cause a phenomenon known as central sensitization or wind-up. This can become a viscous feedback loop where over time you essentially ‘experience pain because you are in pain’.

Blocking these afferent pain signals with local anaesthetic produces an immediate break in the wind-up pain. What is interesting is that over time and with recurrent treatments, many patients will begin to experience pain relief from the nerve blocks that outlasts the expected duration of the anaesthetic itself, and the requirement for the nerve blocks reduces in frequency. While the exact mechanism of this is unknown, it is suspected that in allowing the pain centres to ‘take a breath’ while the pain signals are blocked, this somehow helps to reset these parts of the brain to a more normal wiring or ‘neuroplasticity’. Over time, and in combination with other means of pain management, this may often help reduce the central sensitization, and the requirement for regular interventions.

Botox for Chronic Migraine

Botox, (onabotulinumtoxin A) is an approved injectable treatment for the prevention of headaches in patients with chronic migraine (CM). The definition of CM is quite specific and involves “headaches in 15 days or more per month lasting 4 hours a day or longer, and, in at least 8 of those days the headaches must include several migraine features”. Migraine features includes things like nausea, vomiting, light or sound sensitivity, the presence of a migraine ‘aura’, or headaches being triggered by certain smells or foods (perfumes, red wine, chocolate, and strong cheese are common migraine triggers).

Most often, but not always, migraines are unilateral, occurring on only one side of the head (e.g. behind one eye, temple, or back of head, etc.) and are exceptionally intense, crippling, or stabbing in nature. They are often preceded by an ‘aura’ – the sensation of knowing a migraine will be coming on before it actually starts.

The mechanism of action of Botox in treating CM pain is most likely related to the inhibition or blocking of pain transmitters from the afferent (incoming) neurons to the meningeal (surface layer) of the brain, thereby dampening the peripheral pain signaling to the brain.

The efficacy of Botox as a preventative treatment for CM is attributed to the notion that its extracranial administration decreases the release of nociceptive (pain-producing) mediators, and the sensitivity of the meningeal pain receptors through downregulation of their activity.

The safety and efficacy of onabotulinumtoxin A for CM was demonstrated years ago in what is known as the PREEMPT clinical trial. It was a large multi-national trial. This has now become known as the ‘PREEMPT Protocol’, and involves a specific fixed‐site, fixed‐dose injection paradigm of Botox, injected into 31 prescribed sites via tiny injections to the head and neck region.

The treatment is typically given every 9-12 weeks, although sometimes as little as two to three times a year may be required over time to keep the CM at bay. When used in the correctly selected patients, Botox can be incredibly life-changing for many suffering from CM.

Botox treatment for CM is not covered under OHIP but is covered by most private insurance plans if you meet the inclusion criteria. Patients may also choose to pay privately if they have no coverage via their benefit plan. You can speak to your DSPI physician about whether you may be a candidate for a trial of Botox PREEMPT.

More information on Chronic Migraine can be found here at the Cleveland Clinic site.

Infusion Therapy

At DSPI we offer several IV therapies for chronic pain in our infusion suite. These are delivered by one of our nurses, while being supervised by one of our anaesthetists or qualified pain specialists.

Lidocaine

Lidocaine is a common local anaesthetic that can be delivered by intravenous (IV) infusion to relieve chronic pain. It has also proven to be useful in the treatment of certain types of headaches. Lidocaine is a sodium channel blocker and can block the pain receptors in the brain and spinal cord, making it a particularly effective treatment for neuropathic pain - pain caused by nerve damage or a malfunctioning nervous system.

Conditions lidocaine infusion is used to treat include:

- Chronic regional pain syndrome (CRPS I and II)
- Neuropathic pain (nerve pain)
- Failed back surgery syndrome (FBSS) / Chronic post-surgical pain
- Postherpetic pain
- Chronic diabetic neuropathy
- Fibromyalgia
- Vascular headaches
- Centralised pain
- Widespread pain

Ketamine

Like Lidocaine, Ketamine may also be very useful in treating a variety of chronic pain conditions, and as you will note, the overlap in indications for its use is very similar. However, the mechanism of action is by a different pathway, so in fact Ketamine infusion therapy can be used alone, or often combined with IV lidocaine, to treat pain for patients diagnosed with refractory pain conditions, having failed standard pharmacologic treatments. The primary mechanism of action of Ketamine is thought to be due to antagonism (blocking) of the N-methyl-D-aspartate (NMDA) receptors found in various locations in the central nervous system (CNS).

The activation or engagement of the NMDA receptors plays a major role in cognition, chronic pain, opioid tolerance, and mood regulation; it is considered the main receptor population involved in phenomenon of central sensitization described earlier when discussing the use of anaesthetic nerve blocks. As such, one can only imagine that the blocking of these NMDA receptors may have profound effects on these symptoms.

Due to NMDA receptors playing a significant role in mood regulation, IV Ketamine also has gained significant and growing popularity for the treatment of a number of mental health conditions unresponsive to standard treatment protocols, such as treatment-resistant depression, PTSD and chronic opioid addiction. These mental health indications are discussed separately in the section that follows.

Conditions ketamine infusion is used to treat include:

- Chronic regional pain syndrome (CRPS I and II)
- Neuropathic pain (nerve pain)
- Failed back surgery syndrome (FBSS) / Chronic post-surgical pain
- Postherpetic pain
- Trigeminal neuralgia and atypical facial pain
- Chronic diabetic neuropathy
- Fibromyalgia
- Cluster headaches, migraines, occipital neuralgia
- Centralised pain
- Widespread pain

TMS – Transcranial
Magnetic Stimulation

DSPI is excited to announce our partnership with leading experts in magnetic neurostimulation. In collaboration with Magnetix Health, an evidence-driven TMS service, we offer personalized neurostimulation for individuals with appropriately indicated mental health conditions as assessed by the psychiatric expert team.

Transcranial Magnetic Stimulation (TMS) has emerged as a promising treatment option for various neuropsychiatric disorders. Extensive research has highlighted its potential to alleviate symptoms associated with depression, anxiety, and other mental health conditions. Ongoing clinical trials continue to explore its efficacy across a spectrum of psychiatric disorders because it is safe and effective. It is even contending with antidepressant medications as a first-line option for treatment for depression.

TMS has sustained approval from regulatory authorities such as the U.S. Food and Drug Administration (FDA) and Health Canada, attesting to its safety and efficacy in clinical practice.

TMS therapy has demonstrated notable success in the management of treatment-resistant depression (TRD) and major depressive disorder (MDD), offering rapid and sustained relief for many individuals. Additionally, studies suggest its effectiveness in addressing symptoms of anxiety disorders, obsessive-compulsive disorder (OCD), and post-traumatic stress disorder (PTSD). We have experience treating a range of individuals including first-responders, veterans, and executives.

The mechanism of action underlying TMS involves applying magnetic fields to targeted regions of the brain, specifically modulating neural activity. By stimulating or inhibiting neuronal circuits implicated in mood regulation and cognitive function, TMS fosters neuroplasticity, or brain growth, and restores functional connectivity within the brain.

More information about TMS can be found here at the Magnetix Health site.